Raynaud's disease treated with griseofulvin.

The patient, a 7-year-old girl, with no previous history of circulatory disorder, developed rubella, and a week later a discoloration of her fingers was noted. The index finger of the right hand became purple and cold and then the index finger of her left hand became similarly affected. Other fingers were soon involved (see Fig.) and by the third week some discoloration of the toes was noticed. There was no family history of any similar disorder. On examination at that time she was a healthy-looking girl of average build. The circulatory changes described above were found, involving mainly the fingers. A trophic lesion was present at the tip of the right index finger. The toes were involved, but to a lesser extent. Arterial pulses in the limbs were normal; blood pressure 90/60 mm. Hg. The skin was mildly ichthyotic.